Tangential flow ultrafiltration is a form of filtration in which the direction of liquid flow is perpendicular to the direction of filtration, i.e. the liquid flows in a direction parallel to the membrane and scours the surface of the membrane at the same time so that a gel layer does not form on the membrane surface and a stable ultrafiltration rate is maintained.
Tangential flow ultrafiltration is widely used in research and development, pilot, and industrial production. For large-scale liquid filtration, the tangential flow ultrafiltration method is used to produce a shear force on the surface of the filter media, which reduces the accumulation of filter cake or gel layer and ensures a stable filtration rate.Tangential flow ultrafiltration is mainly used for concentration, wash filtration (desalination and buffer replacement), and size separation of biomolecules. In addition, it can also be used for the removal and clarification of cells and cell debris from fermentation broths or cell culture broths.