In recent years, as the research on SMB technology has intensified, its application areas have been further expanded, from the separation of single petrochemical products to gradually involving fine chemicals, the sugar industry, cosmetics, and the fragrance industry. Natural products have always been the focus of the attention of scientific researchers because of their rich resources, variety, and potential active functions. However, the complex composition of natural products and the low content of active ingredients require the use of modern science and technology to establish an effective separation process in order to prepare products with clear composition, clear efficacy, and controlled active ingredient content. SMB technology has the characteristics of continuous separation, easy operation, and controlled conditions, which are of great importance for the preparation of large quantities of active ingredients of natural products. Many studies have been carried out by Chinese researchers and scholars on the extraction of active ingredients from natural products, including the separation of compounds such as flavonoids, polyphenols, amino acids, peptides, and sugars.