Bio-Oligo 100 Nucleic Acid Synthesizer

Bio-Oligo 100 can synthesize 50μmol-9mmol of DNA/RNA. Equipment using modular design and intelligent software combined with synthesis columns of different specifications can synthesize a certain amount of DNA/RNA, and this system is used in clinical research, nucleic acid drug development and the synthesis of molecular diagnostic probes.

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Features of Bio-Oligo 100 Nucleic Acid Synthesizer

01.

Biocompatibility

Stacked piping design, small dead volume, piping resistant to conventional organic solvents (acetonitrile, toluene), a certain concentration of dichloroacetic acid (3% ~ 10%) and other reagents;

02.

High flow accuracy

PEEK material dual pump head with high flow accuracy and flow accuracy controlled at ± 1%; Flow repeatability: RSD ≤ 0.5%, pump head self-cleaning function;

03.

Multi user management

Modular design that facilitates equipment maintenance, enables multi-user login and management, ensure information security and tracking;

04.

Custom method editing

Process parameters setting module customization, process method self-editing, good human-computer interaction experience;

05.

High degree of automation

Low reagent losses, high degree of automation, monitoring of synthesis pressure throughout, conductivity values, UV detection etc.

06.

High synthesis efficiency

Cycle time: 4.5 ~25min (standard DNA), synthesis efficiency: > 99% for DNA, > 98% for RNA, can synthesize DNA / RNA of different sequence length;

07.

Individually customized

Base monomer bottle quantities can be expanded to a maximum of 18, meeting the needs for the synthesis of modified monomers from a subset of customers;

08.

Compliance with laws and regulations

Software design is compliant with the requirements of relevant laws and regulations such as 21 CFR Part 11.

Bio-Oligo 100 Nucleic Acid Synthesizer Specification

Synthesis scale	50μmol-9mmol
Solvent compatibility	Deprotection reagents, BTT, Thio reagents, etc.
Pump	Piston pump, PEEK material, pump head self-cleaning function, double pump head design, 0~100ml/min
Column reactor	1 pcs
Amidite bottle	Standard 8, expandable to 18
Monomer inlet	1
Waste liquid outlet	8
Operating pressure	15bar (218psi)
Inert gas pressure	0.3~0.35 bar
UV detector	Wavelength range 190~ 400nm, accuracy ±1nm (double channel UV detector is optional)
Conductivity detector	0～999mS/cm
Pipe material	PTFE tube, PEEK tube
Single cycle time	<30min
Synthesis efficiency	>99% for DNA >98% for RNA
Power supply	220V±5% AC
Wattage	900W
Weight	55kg
Dimensions	450570570mm
Operating temperature	10~40℃
Humidity	0.3